8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine

Base Information

• Chemical Name: 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine
• CAS No.: 853642-87-2
• Molecular Formula: C₁₆H₁₅BrFNO₃S
• Molecular Weight: 400.268
• Mol file: 853642-87-2.mol

Synonyms:8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine

Chemical Property of 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine

There total 7 articles about 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride (853642-86-1) + 2-fluorobenzenesulfonyl chloride (2905-21-7) → 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine (853642-87-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h; Heating / reflux;

Reference yield:

8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine (853683-76-8) + 2-fluorobenzenesulfonyl chloride (2905-21-7) → 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine (853642-87-2)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/j.bmcl.2006.12.093

Reference yield:

8-bromo-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one (688363-73-7) → 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine (853642-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: BH₃-DMS / tetrahydrofuran / Heating

2: pyridine / CH₂Cl₂

With pyridine; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.12.093

upstream raw materials:

8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine

2-fluorobenzenesulfonyl chloride

8-bromo-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

2-bromo-6-nitro-phenol

Downstream raw materials:

4-[4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl]-piperazine-1-carboxylic acid tert-butyl ester