C₂₂H₂₀N₂O₆S

Base Information

• Chemical Name: C₂₂H₂₀N₂O₆S
• CAS No.: 1262795-65-2
• Molecular Formula: C₂₂H₂₀N₂O₆S
• Molecular Weight: 440.477
• Mol file: 1262795-65-2.mol

Synonyms:C₂₂H₂₀N₂O₆S

Chemical Property of C₂₂H₂₀N₂O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀N₂O₆S

There total 6 articles about C₂₂H₂₀N₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C19H18N2O6S (1262795-62-9) + propargyl bromide (106-96-7) → C22H20N2O6S (1262795-65-2)

Guidance literature:

C₁₉H₁₈N₂O₆S; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; toluene; mineral oil; at 0 - 18 ℃; for 3h; Inert atmosphere;

DOI:10.1071/CH10359

Reference yield:

C12H13BrN2O4S (1262795-60-7) → C22H20N2O6S (1262795-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / tetrahydrofuran; water / 1.5 h / 90 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 18 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; 1.1: Suzuki coupling;

DOI:10.1071/CH10359

Reference yield:

C11H18BrNO2 (1262795-58-3) → C22H20N2O6S (1262795-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 18 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1.5 h / 18 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / tetrahydrofuran; water / 1.5 h / 90 °C / Microwave irradiation; Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

4.2: 3 h / 0 - 18 °C / Inert atmosphere

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki coupling;

DOI:10.1071/CH10359

upstream raw materials:

C₁₁H₁₈BrNO₂

C₁₂H₁₃BrN₂O₄S

C₁₉H₁₈N₂O₆S

propargyl bromide

Downstream raw materials:

C₄₄H₄₀N₄O₁₂S₂