(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Base Information

Chemical Name:(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene
CAS No.:208719-60-2
Molecular Formula:C₁₈H₁₈FN₃O₄
Molecular Weight:359.357
Hs Code.:

Synonyms:(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Suppliers and Price of (Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Chemical Property:

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Technology Process of (Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

There total 6 articles about (Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N₆ -acetylcytosine

: 167629-24-5
(Z)-4-bromo-2-benzoyloxymethyl-1-fluorobut-1-ene

: 208719-60-2
(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Guidance literature:: With sodium hydrogencarbonate; potassium carbonate; In N-methyl-acetamide;

Reference yield:

: 98-88-4
benzoyl chloride

: 208719-60-2
(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / pyridine / 18 h / Ambient temperature

2: 55 percent / DDQ / CH₂Cl₂; H₂O / 1 h / Ambient temperature

3: 91 percent / N=bromosuccinimide, PPh₃ / CH₂Cl₂ / 18 h / Ambient temperature

4: 30 percent / K₂CO₃ / dimethylformamide / 18 h / 80 °C

With pyridine; N-Bromosuccinimide; potassium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/07328319808004223

Reference yield:

: 208719-57-7
Benzoic acid 2-[1-fluoro-meth-(Z)-ylidene]-4-(4-methoxy-benzyloxy)-butyl ester

: 208719-60-2
(Z)-4-(4-acetylaminopyrimidinone-1-yl)-2-benzoyloxymethyl-1-fluorobut-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / DDQ / CH₂Cl₂; H₂O / 1 h / Ambient temperature

2: 91 percent / N=bromosuccinimide, PPh₃ / CH₂Cl₂ / 18 h / Ambient temperature

3: 30 percent / K₂CO₃ / dimethylformamide / 18 h / 80 °C

With N-Bromosuccinimide; potassium carbonate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1080/07328319808004223