2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

Base Information

Chemical Name:2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone
CAS No.:101210-99-5
Molecular Formula:C₁₆H₂₀N₈O₅
Molecular Weight:404.385
Hs Code.:

Synonyms:2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

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Chemical Property of 2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

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Technology Process of 2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

There total 9 articles about 2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 101231-99-6
3-amino-1-hydroxy-3-methyl-4-phenylbutan-2-one semicarbazone hydrochloride

: 1007-99-4
2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one

: 101210-99-5
2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

Guidance literature:: With triethylamine; In ethanol; for 22h; Heating;

Reference yield:

: 64282-11-7
methyl 2-(phenylmethyl)-2-aminopropionate

: 101210-99-5
2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / diethyl ether / Ambient temperature

2: 98 percent / 1M-sodium hydroxide / H₂O / 1 h / Heating

3: 98 percent / thionyl chloride / 1 h / Heating

4: 58 percent / diethyl ether / Ambient temperature

5: 95 percent / 0.5M-sulphuric acid / dioxane; H₂O / 0.75 h / Heating

6: 98 percent / 1.) hydrazine hydrate, 2.) 0.2M-hydrochloric acid / ethanol / 1.) 2 h, reflux, 2.) r.t. HCl, 5 min reflux

7: 97 percent / sodium hydrogen carbonate / methanol; H₂O / r.t. water, 1 h then 35 deg C,

8: 48 percent / triethylamine / ethanol / 22 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In 1,4-dioxane; methanol; diethyl ether; ethanol; water;

Reference yield:

: 101210-78-0
methyl 2-(2-carboxybenzamido)-2-methyl-3-phenylpropanoate

: 101210-99-5
2-amino-6-(2-benzyl-4-hydroxy-3-oxobutan-2-ylamino)-5-nitropyrimidin-4(3H)-one semicarbazone

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / 1M-sodium hydroxide / H₂O / 1 h / Heating

2: 98 percent / thionyl chloride / 1 h / Heating

3: 58 percent / diethyl ether / Ambient temperature

4: 95 percent / 0.5M-sulphuric acid / dioxane; H₂O / 0.75 h / Heating

5: 98 percent / 1.) hydrazine hydrate, 2.) 0.2M-hydrochloric acid / ethanol / 1.) 2 h, reflux, 2.) r.t. HCl, 5 min reflux

6: 97 percent / sodium hydrogen carbonate / methanol; H₂O / r.t. water, 1 h then 35 deg C,

7: 48 percent / triethylamine / ethanol / 22 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In 1,4-dioxane; methanol; diethyl ether; ethanol; water;