10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione

Base Information

• Chemical Name: 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione
• CAS No.: 74235-95-3
• Molecular Formula: C₂₂H₂₂N₄O₃
• Molecular Weight: 390.442
• Mol file: 74235-95-3.mol

Synonyms:10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione

Chemical Property of 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione

There total 7 articles about 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

10-[2-(3-Methoxy-phenyl)-ethyl]-7,8-dimethyl-10H-benzo[g]pteridine-2,4-dione (74235-94-2) + methyl iodide (74-88-4) → 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione (74235-95-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 23h; Ambient temperature;

DOI:10.1021/ja00535a035

Reference yield:

4-amino-o-xylene (95-64-7) → 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione (74235-95-3)

Guidance literature:

Multi-step reaction with 6 steps

2: 70 percent / LiAlH₄

3: 0.42 g / 0.17 h / 220 °C

4: 0.17 g / NaNO₂ / acetic acid / 1 h / Ambient temperature

5: 69 percent / Na₂S₂O₄ / H₂O; ethanol / 51 h / Ambient temperature

6: 46 percent / K₂CO₃ / dimethylformamide / 23 h / Ambient temperature

With lithium aluminium tetrahydride; sodium dithionite; potassium carbonate; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/ja00535a035

Reference yield:

(3,4-Dimethyl-phenyl)-[2-(3-methoxy-phenyl)-ethyl]-amine (74235-90-8) → 10-[2-(3-Methoxy-phenyl)-ethyl]-3,7,8-trimethyl-10H-benzo[g]pteridine-2,4-dione (74235-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 0.42 g / 0.17 h / 220 °C

2: 0.17 g / NaNO₂ / acetic acid / 1 h / Ambient temperature

3: 69 percent / Na₂S₂O₄ / H₂O; ethanol / 51 h / Ambient temperature

4: 46 percent / K₂CO₃ / dimethylformamide / 23 h / Ambient temperature

With sodium dithionite; potassium carbonate; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/ja00535a035

upstream raw materials:

10-[2-(3-Methoxy-phenyl)-ethyl]-7,8-dimethyl-10H-benzo[g]pteridine-2,4-dione

methyl iodide

(3,4-Dimethyl-phenyl)-[2-(3-methoxy-phenyl)-ethyl]-amine

N-(3,4-Dimethyl-phenyl)-2-(3-methoxy-phenyl)-acetamide

Downstream raw materials:

3,7,8-trimethyl-10-(3-hydroxyphenethyl)isoalloxazine

5-Ethyl-10-[2-(3-hydroxy-phenyl)-ethyl]-3,7,8-trimethyl-5,10-dihydro-1H-benzo[g]pteridine-2,4-dione

C₂₃H₂₆N₄O₄

5-Ethyl-4a-hydroxy-10-[2-(3-hydroxy-phenyl)-ethyl]-3,7,8-trimethyl-5,10-dihydro-4aH-benzo[g]pteridine-2,4-dione