ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate

Base Information

• Chemical Name: ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate
• CAS No.: 1220349-95-0
• Molecular Formula: C₁₉H₂₅NO₄
• Molecular Weight: 331.412
• Mol file: 1220349-95-0.mol

Synonyms:ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate

Chemical Property of ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate

There total 1 articles about ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

benzyl 1-(phenylsulfonyl)pent-4-enylcarbamate (1220349-81-4) + ethyl 2-(trimethylsilylmethyl)acrylate (74976-84-4) → ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate (1220349-95-0)

Guidance literature:

With Bi(OTF)3*4H₂O; In dichloromethane; at 22 ℃; for 94h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200900710

Reference yield: 64.0%

ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate (1220349-95-0) → ethyl 5-(benzyloxycarbonylamino)cyclohex-1-enecarboxylate (1220350-07-1)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 42h; Inert atmosphere; Reflux;

DOI:10.1002/adsc.200900710

Reference yield: 37.0%

ethyl 4-(((benzyloxy)carbonyl)amino)-2-methyleneoct-7-enoate (1220349-95-0) → (Z/E)-diethyl 4,11-bis(benzyloxycarbonylamino)-2,13-dimethylenetetradec-7-enedioate

Guidance literature:

With Grubbs catalyst first generation; In toluene; for 46h; Inert atmosphere; Reflux;

DOI:10.1002/adsc.200900710

upstream raw materials:

benzyl 1-(phenylsulfonyl)pent-4-enylcarbamate

ethyl 2-(trimethylsilylmethyl)acrylate

Downstream raw materials:

ethyl 5-(benzyloxycarbonylamino)cyclohex-1-enecarboxylate