3β-benzoyloxylanost-7-en-15α-ol

Base Information

• Chemical Name: 3β-benzoyloxylanost-7-en-15α-ol
• CAS No.: 119288-15-2
• Molecular Formula: C₃₇H₅₆O₃
• Molecular Weight: 548.85
• Mol file: 119288-15-2.mol

Synonyms:3β-benzoyloxylanost-7-en-15α-ol

Chemical Property of 3β-benzoyloxylanost-7-en-15α-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-benzoyloxylanost-7-en-15α-ol

There total 14 articles about 3β-benzoyloxylanost-7-en-15α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

15-oxolanost-7-en-3β-yl benzoate (108348-03-4) → Benzoic acid (3S,5R,9R,10R,13R,14R,15R,17R)-17-((R)-1,5-dimethyl-hexyl)-15-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester + 3β-benzoyloxylanost-7-en-15α-ol (119288-15-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

(3β,20R)-4,4-dimethylcholesta-5,7-dien-3-ol (53296-71-2) → 3β-benzoyloxylanost-7-en-15α-ol (119288-15-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: H₂ / 10 percent Pd/C / ethyl acetate

2.1: pyridine

3.1: 70 percent / HCl gas / CH₂Cl₂ / 0.5 h / -20 °C

4.1: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

5.1: BF₃-etherate / benzene / 0.5 h / 25 °C

6.1: m-chloroperbenzoic acid / diethyl ether / 0.17 h

6.2: 40 percent / BF₃-etherate / benzene / 0.25 h / 5 °C

7.1: 42 percent / conc. aq. HCl / ethanol; CH₂Cl₂ / 8 h / 70 °C

8.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 0.25 h

8.2: 79 percent / tetrahydrofuran; 2-methyl-propan-2-ol / 1.2 h / 20 °C

9.1: 47 percent / NaBH₄ / tetrahydrofuran; methanol / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; benzene;

Reference yield:

32-nor-lanosta-5,7-dien-3-one (7638-67-7) → 3β-benzoyloxylanost-7-en-15α-ol (119288-15-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 63 percent / LiAlH₄ / tetrahydrofuran / 1.5 h

2.1: H₂ / 10 percent Pd/C / ethyl acetate

3.1: pyridine

4.1: 70 percent / HCl gas / CH₂Cl₂ / 0.5 h / -20 °C

5.1: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

6.1: BF₃-etherate / benzene / 0.5 h / 25 °C

7.1: m-chloroperbenzoic acid / diethyl ether / 0.17 h

7.2: 40 percent / BF₃-etherate / benzene / 0.25 h / 5 °C

8.1: 42 percent / conc. aq. HCl / ethanol; CH₂Cl₂ / 8 h / 70 °C

9.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 0.25 h

9.2: 79 percent / tetrahydrofuran; 2-methyl-propan-2-ol / 1.2 h / 20 °C

10.1: 47 percent / NaBH₄ / tetrahydrofuran; methanol / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; benzene;

upstream raw materials:

15-oxolanost-7-en-3β-yl benzoate

(3β,20R)-4,4-dimethylcholesta-5,7-dien-3-ol

32-nor-lanosta-5,7-dien-3-one

32-nor-lanost-8(14)-en-3β-ol

Downstream raw materials:

15α-fluoro-8-lanost-8-en-3β-yl benzoate

15α-fluorolanost-7-en-3β-yl benzoate