1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Base Information

Chemical Name:1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417528-15-4
Molecular Formula:C₃₃H₂₇F₄N₅O₂S
Molecular Weight:633.669
Hs Code.:

1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Synonyms:1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 14 articles about 1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417528-13-2
1-(5-((2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)vinyl acetate

: 1417528-15-4
1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With hydrogenchloride; water; In isopropyl alcohol; at 20 ℃;

Reference yield:

: 1417528-14-3
2-(4-fluorobenzylthio)-1-((5-(1-hydroxyethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

: 1417528-15-4
1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With manganese(IV) oxide; In 1,4-dioxane; at 70 ℃; for 2h;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1417528-15-4
1-((5-acetyl-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-fluorobenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 13 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

1.2: 1 h / Cooling with ice

2.1: ethanol / 2 h / Reflux

2.2: 1 h / Reflux

3.1: acetic acid; dihydrogen peroxide / water; dichloromethane / 1.5 h / 20 - 35 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

5.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

6.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

7.1: tetraethoxy orthosilicate / ethanol / 5 h / Inert atmosphere; Reflux

8.1: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

9.1: 8 h / Reflux

10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide / acetonitrile / 20 °C

11.1: manganese(IV) oxide / 1,4-dioxane / 3 h / 70 - 80 °C

12.1: tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere

13.1: manganese(IV) oxide / 1,4-dioxane / 2 h / 70 °C

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraethoxy orthosilicate; diphenyl phosphoryl azide; water; dihydrogen peroxide; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;