Technology Process of benzyl (R)-1-(tert-butyldimethylsilyloxy)-4-methylpentan-3-ylcarbamate
There total 3 articles about benzyl (R)-1-(tert-butyldimethylsilyloxy)-4-methylpentan-3-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / -20 °C
1.2: 84 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C
2.1: 83 percent / silver benzoate; triethylamine / -35 - 20 °C
3.1: 71 percent / lithium borohydride / tetrahydrofuran; methanol / 0 - 20 °C
4.1: 99 percent / imidazole / dimethylformamide; tetrahydrofuran
With
1H-imidazole; lithium borohydride; silver benzoate; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol070415q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / lithium borohydride / tetrahydrofuran; methanol / 0 - 20 °C
2: 99 percent / imidazole / dimethylformamide; tetrahydrofuran
With
1H-imidazole; lithium borohydride;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol070415q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / silver benzoate; triethylamine / -35 - 20 °C
2: 71 percent / lithium borohydride / tetrahydrofuran; methanol / 0 - 20 °C
3: 99 percent / imidazole / dimethylformamide; tetrahydrofuran
With
1H-imidazole; lithium borohydride; silver benzoate; triethylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol070415q
