2-(4-Methoxyphenyl)imidazo[2,1-a]isoquinoline

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)imidazo[2,1-a]isoquinoline
• CAS No.: 61001-01-2
• Molecular Formula: C₁₈H₁₄N₂O
• Molecular Weight: 274.322
• UNII: K6XME2MS8B
• Nikkaji Number: J61.461K
• Wikidata: Q107889000
• ChEMBL ID: CHEMBL1561928

Synonyms:2-(4-methoxyphenyl)imidazo[2,1-a]isoquinoline;K6XME2MS8B;MLS000121240;2-(4-Methoxy-phenyl)-imidazo[2,1-a]isoquinoline;2-(4-METHOXYPHENYL)IMIDAZO(2,1-A)ISOQUINOLINE;SMR000118707;61001-01-2;Imidazo(2,1-a)isoquinoline, 2-(4-methoxyphenyl)-;2-(p-methoxyphenyl)imidazo(2,1-a)isoquinoline;UNII-K6XME2MS8B;Oprea1_083186;Oprea1_865748;cid_746061;CHEMBL1561928;NIOSH/NI3025000;BDBM49357;ZYWYGWRRHDDHSN-UHFFFAOYSA-N;HMS2340B21;STK804561;AKOS004118341;NI30250000;2-(4-methoxyphenyl)imidaz[2,1-a]isoquinoline;2-(p-Methoxyphenyl)imidazo(2,1-a)isoquinoline;MLS-0086420.0001;Imidazo(2,1-a)isoquinoline, 2-(p-methoxyphenyl)-

Chemical Property of 2-(4-Methoxyphenyl)imidazo[2,1-a]isoquinoline

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 274.110613074
• Heavy Atom Count: 21
• Complexity: 353

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CN3C=CC4=CC=CC=C4C3=N2

Technology Process of 2-(4-Methoxyphenyl)imidazo[2,1-a]isoquinoline

There total 11 articles about 2-(4-Methoxyphenyl)imidazo[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isoquinoline (119-65-3) + 4-methoxybenzenehydroximic acid chloride (38435-51-7,74903-79-0) + α-bromoacetophenone (70-11-1) → 2-(4-methoxyphenyl)imidazo[2,1-a]isoquinoline (61001-01-2)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 4h;

DOI:10.1016/j.tetlet.2013.04.126

Reference yield: 86.0%

isoquinolin-1-ylamine (1532-84-9) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-methoxyphenyl)imidazo[2,1-a]isoquinoline (61001-01-2)

Guidance literature:

1.) 15 min., room temp., CHCl₃, 2.) 15 min., heating on a steam bath;

Reference yield: 84.0%

isoquinolin-1-ylamine (1532-84-9) + α-tosyloxy-p-methoxyacetophenone (93435-57-5) → 2-(4-methoxyphenyl)imidazo[2,1-a]isoquinoline (61001-01-2)

Guidance literature:

With sodium carbonate; N-butylpyridinium tetrafluoroborate; at 20 ℃; for 1h;

upstream raw materials:

isoquinolin-1-ylamine

2-Bromo-4'-methoxyacetophenone

N-(p-Methoxyphenacyl)-isoquinoliniumbromide

isoquinoline

Downstream raw materials:

1-[2-(4-Methoxy-phenyl)-imidazo[2,1-a]isoquinolin-3-yl]-ethanone

2-(4-methoxyphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

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