N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

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Chemical Name:N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide
CAS No.:479546-90-2
Molecular Formula:C₂₁H₂₆N₄O₄
Molecular Weight:398.462
Hs Code.:

<i>N</i>-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-2-yl}-2,2-dimethyl-propionamide

Synonyms:N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

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Chemical Property of N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

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Technology Process of N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

There total 4 articles about N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 479546-83-3
N-[6-(2,5-dimethoxy-phenylethynyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide

: 479546-90-2
N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

Guidance literature:: With ammonium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; for 20h; under 2585.74 Torr;
DOI:10.1002/jhet.5570390433

Reference yield:

: 1201-38-3
2',5'-dimethoxyacetophenone

: 479546-90-2
N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / PCl₅ / benzene / 5 h / Heating

2: 81 percent / KOH / ethanol / 48 h / Heating

3: 36 percent / CuI; Et₃N / tetrakis(triphenylphosphane)palladium⁽⁰⁾ / dimethylformamide / 72 h / 20 °C

4: 93 percent / H₂; NH₄OH / Pd/C / dimethylformamide; H₂O; tetrahydrofuran / 20 h / 2585.74 Torr

With potassium hydroxide; ammonium hydroxide; copper(l) iodide; phosphorus pentachloride; hydrogen; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; benzene; 3: Sonogashira coupling reaction;
DOI:10.1002/jhet.5570390433

Reference yield:

: 22944-08-7
2-ethynyl-1,4-dimethoxybenzene

: 479546-90-2
N-{6-[2-(2,5-dimethoxy-phenyl)-ethyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / CuI; Et₃N / tetrakis(triphenylphosphane)palladium⁽⁰⁾ / dimethylformamide / 72 h / 20 °C

2: 93 percent / H₂; NH₄OH / Pd/C / dimethylformamide; H₂O; tetrahydrofuran / 20 h / 2585.74 Torr

With ammonium hydroxide; copper(l) iodide; hydrogen; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Sonogashira coupling reaction;
DOI:10.1002/jhet.5570390433