(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

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Chemical Name:(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile
CAS No.:1422177-20-5
Molecular Formula:C₂₂H₂₉N₃
Molecular Weight:335.492
Hs Code.:

Synonyms:(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

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Chemical Property of (S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

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Technology Process of (S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

There total 2 articles about (S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 14918-21-9
5-hexynonitrile

: 51207-66-0
(S)-2-(1-pyrrolidinylmethyl)pyrrolidine

: 100-52-7
benzaldehyde

: 1422177-20-5
(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

Guidance literature:: With copper(I) bromide; In toluene; at 25 ℃; for 36h; diastereoselective reaction; Molecular sieve;
DOI:10.1021/jo302534f

Reference yield:

: 1422177-07-8
(S)-1-((S)-1-phenylundec-2-yn-1-yl)-2-(pyrrolidin-1-ylmethyl)-pyrrolidine

: 1422177-20-5
(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

1.2: 2 h / 0 - 25 °C

2.1: copper(I) bromide / toluene / 36 h / 25 °C / Molecular sieve

With copper(l) iodide; copper(I) bromide; In 1,4-dioxane; toluene;
DOI:10.1021/jo302534f

Reference yield: 81.0%

: 1422177-20-5
(S)-7-phenyl-7-((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)hept-5-ynenitrile

: (R)-7-phenyl-1-cyanohepta-5,6-diene

: 1422177-45-4
C₉H₁₆N₂

Guidance literature:: With copper(l) iodide; In 1,4-dioxane; at 100 ℃; for 18h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo302534f