Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

Base Information

Chemical Name:Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester
CAS No.:167387-22-6
Molecular Formula:C₁₆H₂₄O₆S
Molecular Weight:344.429
Hs Code.:

Synonyms:Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

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Chemical Property of Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

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Technology Process of Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

There total 7 articles about Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 167387-22-6
Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: CuBr-Me₂S / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C

2: sodium tetrahydroborate / methanol / -12 °C

3: diphenylether / 3 h / Heating

4: hydrogen / palladium on activated charcoal / ethanol / Ambient temperature

5: dmap; triethylamine / dichloromethane / 1 h / 0 °C

With dmap; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diphenylether; ethanol; dichloromethane;
DOI:10.1248/cpb.43.901

Reference yield:

: 146830-38-8
(1S,4R,4aS,5R,8S,8aR)-8-Methoxymethoxy-1,4,4a,5,8,8a-hexahydro-1,4-methano-naphthalen-5-ol

: 167387-22-6
Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dipyridinium dichromate / N,N-dimethyl-formamide / Ambient temperature

2: CuBr-Me₂S / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C

3: sodium tetrahydroborate / methanol / -12 °C

4: diphenylether / 3 h / Heating

5: hydrogen / palladium on activated charcoal / ethanol / Ambient temperature

6: dmap; triethylamine / dichloromethane / 1 h / 0 °C

With dmap; sodium tetrahydroborate; dipyridinium dichromate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diphenylether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.901

Reference yield:

: 167387-08-8
(1S,4R,4aS,8S,8aR)-8-Methoxymethoxy-4,4a,8,8a-tetrahydro-1H-1,4-methano-naphthalen-5-one

: 167387-22-6
Methanesulfonic acid (1S,3S,4R)-4-methoxymethoxy-3-(3-methoxy-phenyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: CuBr-Me₂S / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C

2: sodium tetrahydroborate / methanol / -12 °C

3: diphenylether / 3 h / Heating

4: hydrogen / palladium on activated charcoal / ethanol / Ambient temperature

5: dmap; triethylamine / dichloromethane / 1 h / 0 °C

With dmap; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diphenylether; ethanol; dichloromethane;
DOI:10.1248/cpb.43.901