2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol

Base Information

• Chemical Name: 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol
• CAS No.: 864269-05-6
• Molecular Formula: C₃₀H₄₁NO₃
• Molecular Weight: 463.66
• Mol file: 864269-05-6.mol

Synonyms:2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol

Chemical Property of 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol

There total 6 articles about 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(2R,3S)-2-acetoxy-3-dibenzylaminobutyl]cyclohex-2-enone (864268-99-5) → 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol (864269-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; hexane / 4 h / -78 - 20 °C

2: 81 mg / pyridine; DMAP / 20 °C

With pyridine; dmap; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2005.06.024

Reference yield:

2-[(2R,3S)-3-dibenzylamino-2-hydroxybutyl]cyclohex-2-enone ethylene acetal (864268-98-4) → 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol (864269-05-6)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine; DMAP / 20 °C

2: 80 mg / aq. HCl / tetrahydrofuran / 1 h / 20 °C

3: tetrahydrofuran; hexane / 4 h / -78 - 20 °C

4: 81 mg / pyridine; DMAP / 20 °C

With pyridine; hydrogenchloride; dmap; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2005.06.024

Reference yield:

Acetic acid (1R,2S)-2-dibenzylamino-1-(1,4-dioxa-spiro[4.5]dec-6-en-6-ylmethyl)-propyl ester → 2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-1-butylcyclohex-2-en-1-ol (864269-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 mg / aq. HCl / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran; hexane / 4 h / -78 - 20 °C

3: 81 mg / pyridine; DMAP / 20 °C

With pyridine; hydrogenchloride; dmap; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2005.06.024

upstream raw materials:

acetic anhydride

2-[(2R,3S)-2-acetoxy-3-dibenzylaminobutyl]cyclohex-2-enone

2-[(2R,3S)-3-dibenzylamino-2-hydroxybutyl]cyclohex-2-enone ethylene acetal

6-bromo-1,4-dioxaspiro[4,5]dec-6-ene

Downstream raw materials:

2-[(2R,3S)-2-acetoxy-3-(dibenzylamino)butyl]-3-butylcyclohex-2-enone