C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine

Base Information

• Chemical Name: C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine
• CAS No.: 935518-59-5
• Molecular Formula: C₁₉H₂₂F₃N₃
• Molecular Weight: 349.399

Synonyms:C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine

Chemical Property of C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine

Chemical Property:

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Technology Process of C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine

There total 4 articles about C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile (935517-64-9) → C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine (935518-59-5)

Guidance literature:

With dimethyl sulfide borane; In tetrahydrofuran; at 20 ℃; for 8h; Reflux;

DOI:10.1021/jm300780p

Reference yield:

2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (116548-04-0) → C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine (935518-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 12 h / Reflux

3: dimethyl sulfide borane / tetrahydrofuran / 8 h / 20 °C / Reflux

With 18-crown-6 ether; dimethyl sulfide borane; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm300780p

Reference yield:

2-chloro-6-(trifluoromethyl)nicotinonitrile (386704-06-9) → C-(4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-methylamine (935518-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 12 h / Reflux

2: dimethyl sulfide borane / tetrahydrofuran / 8 h / 20 °C / Reflux

With 18-crown-6 ether; dimethyl sulfide borane; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm300780p

upstream raw materials:

4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

2-chloro-6-(trifluoromethyl)nicotinonitrile

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