4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

Base Information

Chemical Name:4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile
CAS No.:935517-64-9
Molecular Formula:C₁₉H₁₈F₃N₃
Molecular Weight:345.367
Hs Code.:

Synonyms:4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

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Technology Process of 4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

There total 3 articles about 4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116548-04-0
2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 935517-64-9
4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 3 h / Reflux

2: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 12 h / Reflux

With 18-crown-6 ether; potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300780p

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 386704-06-9
2-chloro-6-(trifluoromethyl)nicotinonitrile

: 935517-64-9
4-benzyl-6'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; for 12h; Reflux;
DOI:10.1021/jm300780p