[(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester

Base Information

• Chemical Name: [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester
• CAS No.: 86323-69-5
• Molecular Formula: C₁₉H₂₇NO₅S
• Molecular Weight: 381.493
• Mol file: 86323-69-5.mol

Synonyms:[(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester

Chemical Property of [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester

There total 2 articles about [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl N-(4-propoxyphenyl)glycinate (70350-96-8) + 3-(Acetylthio)-2-methylpropionyl chloride (64805-64-7) → [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester (86323-69-5)

Guidance literature:

With potassium carbonate; In dichloromethane; for 2h; Heating;

DOI:10.1021/jm00363a011

Reference yield:

4-propoxyaniline (4469-80-1) → [(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester (86323-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / sodium acetate trihydrate / 4 h / 110 °C

2: 100 percent / K₂CO₃ / CH₂Cl₂ / 2 h / Heating

With sodium acetate; potassium carbonate; In dichloromethane;

DOI:10.1021/jm00363a011

Reference yield: 52.0%

[(3-Acetylsulfanyl-2-methyl-propionyl)-(4-propoxy-phenyl)-amino]-acetic acid ethyl ester (86323-69-5) → N-(3-mercapto-2-methylpropionyl)-N-(4-propoxyphenyl)glycine (86323-96-8)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jm00363a011

upstream raw materials:

ethyl N-(4-propoxyphenyl)glycinate

3-(Acetylthio)-2-methylpropionyl chloride

4-propoxyaniline

Downstream raw materials:

N-(3-mercapto-2-methylpropionyl)-N-(4-propoxyphenyl)glycine