Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Base Information

• Chemical Name: Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide
• CAS No.: 104502-97-8
• Molecular Formula: C₂₃H₂₂N₄O₃S
• Molecular Weight: 434.519
• Mol file: 104502-97-8.mol

Synonyms:Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Chemical Property of Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide

There total 4 articles about Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyrrolidine (123-75-1) + Nα-(8-Chinolinsulfonyl)-4-cyanphenylalanin-4'-nitrophenylester (104502-95-6) → Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide (104502-97-8)

Guidance literature:

In pyridine; for 24h; Ambient temperature;

Reference yield:

quinoline-8-sulfonyl chloride (18704-37-5) → Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide (104502-97-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / 1M KOH / diethyl ether / 24 h / Ambient temperature

2: 60 percent / DCC / pyridine / 1.) 2 d, 0 deg C; 2.) 2 h, room temp.

3: 93 percent / pyridine / 24 h / Ambient temperature

With potassium hydroxide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether;

Reference yield:

Nα-(8-Chinolinsulfonyl)-4-cyanphenylalanin (104502-94-5) → Quinoline-8-sulfonic acid [(S)-1-(4-cyano-benzyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-amide (104502-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / DCC / pyridine / 1.) 2 d, 0 deg C; 2.) 2 h, room temp.

2: 93 percent / pyridine / 24 h / Ambient temperature

With dicyclohexyl-carbodiimide; In pyridine;

upstream raw materials:

pyrrolidine

N_α-(8-Chinolinsulfonyl)-4-cyanphenylalanin-4'-nitrophenylester

quinoline-8-sulfonyl chloride

N_α-(8-Chinolinsulfonyl)-4-cyanphenylalanin

Downstream raw materials:

4-[(S)-3-Oxo-3-pyrrolidin-1-yl-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide

4-[(S)-3-Oxo-3-pyrrolidin-1-yl-2-(quinoline-8-sulfonylamino)-propyl]-benzamidine; hydriodide

4-[(S)-3-Oxo-3-pyrrolidin-1-yl-2-(quinoline-8-sulfonylamino)-propyl]-thiobenzamide