ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Base Information

Chemical Name:ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate
CAS No.:213976-27-3
Molecular Formula:C₂₉H₃₅N₃O₄Si
Molecular Weight:517.7
Hs Code.:

Synonyms:ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Suppliers and Price of ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

There total 14 articles about ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 213976-26-2
ethyl (2R,3S,4S)-4-(4-tert-butyldimethylsilyloxyphenyl)-4-tert-butyldiphenylsilyloxy-2-chloromethylsulfonyloxy-3-methylbutanoate

: 172170-21-7
ethyl (2S,3S,4S)-2-azido-4-(4-tert-butyldimethylsilyloxyphenyl)-4-tert-butyldiphenylsilyloxy-3-methylbutanoate

: 213976-27-3
ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 20h;
DOI:10.1016/S0040-4020(98)00647-4

Reference yield: 49.0%

: 213976-28-4
ethyl (2R,3S,4S)-4-(4-tert-butyldimethylsilyloxyphenyl)-4-tert-butyldiphenylsilyloxy-2-methanesulfonyloxy-3-methylbutanoate

: 213976-27-3
ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 16h;
DOI:10.1016/S0040-4020(98)00647-4

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 213976-27-3
ethyl (2S,3S,4S)-2-azido-4-tert-butyldiphenylsilyloxy-4-(4-hydroxyphenyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 10 steps

1: 36 percent / Zn dust / benzene / 1.5 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: Amano P lipase / various solvent(s) / 7 h / 33 °C / Enzymatic reaction

4: 97 percent / imidazole; 4-dimethylaminopyridine / CH₂Cl₂ / 44 h / 20 °C

5: 99 percent / HAl(i-Bu)2 / toluene / 1 h / -78 °C

6: oxalyl chloride; Et₃N / CH₂Cl₂; dimethylsulfoxide / 1.67 h / -78 °C

7: tert-BuLi / tetrahydrofuran; pentane / 2 h / -78 °C

8: 11 percent / O₃; dimethylsulfide / CH₂Cl₂ / 1.5 h / -78 °C

9: 91 percent / pyridine / 12 h / 20 °C

10: 35 percent / NaN₃ / dimethylformamide / 20 h / 60 °C

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; sodium azide; oxalyl dichloride; dimethylsulfide; Amano P lipase; tert.-butyl lithium; diisobutylaluminium hydride; ozone; triethylamine; zinc; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; pentane; benzene; 1: Addition / 2: Reduction / 3: Acetylation / 4: Substitution / 5: reductive deacetylation / 6: Oxidation / 7: Addition / 8: ozonolysis / 9: Substitution / 10: Substitution;
DOI:10.1016/S0040-4020(98)00647-4