(R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Base Information

• Chemical Name: (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile
• CAS No.: 444728-19-2
• Molecular Formula: C₁₅H₁₃ClN₂S
• Molecular Weight: 288.801
• Mol file: 444728-19-2.mol

Synonyms:(R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Chemical Property of (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

There total 2 articles about (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

→ (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile (444728-19-2)

Guidance literature:

Reference yield:

4,5,6,7-tetrahydrothieno[3,2-c]pyridine (54903-50-3) + trimethylsilyl cyanide (7677-24-9) + 2-chloro-benzaldehyde (89-98-5) → (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile (444728-17-0) + (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile (444728-19-2)

Guidance literature:

With 5,10,15,20-tetrakis(4-aminophenyl)porphyrin-Cu(II) and (R)-6,6'-dichloro-2,2'-diethoxy-1,1'-binaphthyl-4,4'-dialdehyde-derived homochiral covalent organic framework; In ethanol; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Overall yield = 45 percent; enantioselective reaction; Catalytic behavior; Irradiation;

DOI:10.1021/jacs.0c04722

Reference yield: 96.4%

(R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile (444728-19-2) → (+/-)-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) potassium acetate (929200-21-5)

Guidance literature:

With potassium hydroxide; ethanol; N-benzyl-N,N,N-triethylammonium chloride; water; for 12h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

trimethylsilyl cyanide

2-chloro-benzaldehyde

Downstream raw materials:

(+/-)-(2-chlorophenyl)-(4,5,6,7-4H-thieno[3,2,-c]pyrid-5-yl) potassium acetate

sodium (+/-)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate