4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Base Information

Chemical Name:4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate
CAS No.:918164-17-7
Molecular Formula:C₃₃H₃₅NO₁₁
Molecular Weight:621.641
Hs Code.:

4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Synonyms:4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Suppliers and Price of 4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

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Chemical Property of 4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

There total 8 articles about 4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608-25-3
2-methylbenzene-1,3-diol

: 918164-17-7
4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / acetic acid / 48 h / Heating

2: 81 percent / boron trifluoride etherate / CH₂Cl₂ / 14 h

3: 83 percent / H₂ / palladium on carbon / tetrahydrofuran / 6 h

4: 31 mg / CH₂Cl₂; pyridine / 3.5 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; dichloromethane; acetic acid;
DOI:10.1021/ja065793p

Reference yield:

: 53596-60-4
methyl 3-allyl-4-hydroxybenzoate

: 918164-17-7
4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / pyridine / 14 h / 20 °C

2: 99 percent / Grubbs' second generation catalyst / CH₂Cl₂ / 14 h

3: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 14 h / Heating

4: 223 mg / pyridine / 48 h / 20 °C

5: oxalyl chloride; DMF / CH₂Cl₂ / 2.5 h

6: 31 mg / CH₂Cl₂; pyridine / 3.5 h / 20 °C

With lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/ja065793p

Reference yield:

: 918164-15-5
methyl 4-acetoxy-3-allylbenzoate

: 918164-17-7
4-((7-((3aR,4R,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1.3]dioxolo[4,5-c]pyran-4-yloxy)-8-methyl-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl) phenyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Grubbs' second generation catalyst / CH₂Cl₂ / 14 h

2: lithium hydroxide / tetrahydrofuran; methanol; H₂O / 14 h / Heating

3: 223 mg / pyridine / 48 h / 20 °C

4: oxalyl chloride; DMF / CH₂Cl₂ / 2.5 h

5: 31 mg / CH₂Cl₂; pyridine / 3.5 h / 20 °C

With lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/ja065793p