N-benzyloxy-2-hydroxy-3-methylbutyramide

Base Information

• Chemical Name: N-benzyloxy-2-hydroxy-3-methylbutyramide
• CAS No.: 752235-38-4
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.272
• Mol file: 752235-38-4.mol

Synonyms:N-benzyloxy-2-hydroxy-3-methylbutyramide

Chemical Property of N-benzyloxy-2-hydroxy-3-methylbutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-benzyloxy-2-hydroxy-3-methylbutyramide

There total 5 articles about N-benzyloxy-2-hydroxy-3-methylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-benzyloxy-5-isopropyl-oxazolidin-2,4-dione (752235-28-2) → N-benzyloxy-2-hydroxy-3-methylbutyramide (752235-38-4)

Guidance literature:

With sodium methylate; In methanol; for 1h; Heating;

DOI:10.1039/b404950k

Reference yield: 60.0%

N-(benzyloxy)-2-bromo-3-methylbutanamide → N-benzyloxy-2-hydroxy-3-methylbutyramide (752235-38-4)

Guidance literature:

With water; sodium carbonate; dimethyl sulfoxide; In acetonitrile; at 60 ℃; for 18h;

DOI:10.1002/ejoc.202100088

Reference yield:

2-hydroxy-3-methylbutanenitrile (15344-34-0) → N-benzyloxy-2-hydroxy-3-methylbutyramide (752235-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.17 h / 20 °C

2: CH₂Cl₂ / 20 °C

3: 1.34 g / aq. HCl / tetrahydrofuran / 0.5 h / cooling

4: 89 percent / NaOMe / methanol / 1 h / Heating

With hydrogenchloride; sodium methylate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/b404950k

upstream raw materials:

3-benzyloxy-5-isopropyl-oxazolidin-2,4-dione

2-hydroxy-3-methylbutanenitrile

Refernces

• 1、 Kurz, Thomas,Widyan, Khalid. "O-Protected 3-hydroxy-oxazolidin-2,4-diones: Novel precursors in the synthesis of α-hydroxyhydroxamic acids". . p. 2023 - 2027. Retrieved 2007/10/03.