Technology Process of 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanol
There total 5 articles about 1-(benzo[d]thiazol-2-yl)-2-(4-octylphenoxy)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,3-Benzothiazole;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
C16H24O2;
In
diethyl ether; hexane;
at -78 - 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/jm500192s
- Guidance literature:
-
With
sodium hypochlorite; sodium hydrogencarbonate; sodium bromide;
In
water; ethyl acetate; toluene;
at 0 ℃;
for 1.25h;
With
n-butyllithium;
In
diethyl ether; hexane;
at -78 - 20 ℃;
for 3.25h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 5 h / Reflux
2.1: diisobutylaluminium hydride / diethyl ether; hexane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / water; ethyl acetate; toluene / 1 h / 0 °C
4.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere
4.2: 2.5 h / -78 - 20 °C / Inert atmosphere
With
sodium hypochlorite; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; sodium bromide;
In
diethyl ether; hexane; water; ethyl acetate; acetone; toluene;
DOI:10.1021/jm500192s