ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate

Base Information

• Chemical Name: ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate
• CAS No.: 85465-52-7
• Molecular Formula: C₁₃H₁₅Br₂FO₃
• Molecular Weight: 398.067
• Mol file: 85465-52-7.mol

Synonyms:ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate

Chemical Property of ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate

There total 6 articles about ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(3'-methoxyphenyl)-4-fluoro-2-butenoate (85465-51-6) → ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate (85465-52-7)

Guidance literature:

With bromine; In tetrachloromethane; at -5 ℃; for 3h;

DOI:10.1021/ja00323a050

Reference yield:

2-bromo-3'-methoxyacetophenone (5000-65-7) → ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate (85465-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / KHF₂ / various solvent(s) / 3 h / 100 °C

2: 80 percent / NaH / toluene / 0.5 h / < 15 deg C

3: Br₂ / CCl₄ / 3 h / -5 °C

With potassium hydrogen bifluoride; bromine; sodium hydride; In tetrachloromethane; toluene;

DOI:10.1021/ja00323a050

Reference yield:

2-fluoro-1-(3-methoxyphenyl)ethan-1-one (85465-50-5) → ethyl 2,3-dibromo-3-(3'-methoxyphenyl)-4-fluorobutyrate (85465-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH / toluene / 0.5 h / < 15 deg C

2: Br₂ / CCl₄ / 3 h / -5 °C

With bromine; sodium hydride; In tetrachloromethane; toluene;

DOI:10.1021/ja00323a050

upstream raw materials:

(E)-4-Fluoro-3-(3-methoxy-phenyl)-but-2-enoic acid ethyl ester

ethyl 3-(3'-methoxyphenyl)-4-fluoro-2-butenoate

2-bromo-3'-methoxyacetophenone

2-fluoro-1-(3-methoxyphenyl)ethan-1-one

Downstream raw materials:

ethyl 2-bromo-3-(3'-methoxyphenyl)-4-fluoro-2-butenoate

(E)-β-fluoromethylene-m-tyramine

MDL 72394

(E)-2-Amino-4-fluoro-3-(3-methoxy-phenyl)-but-3-enoic acid ethyl ester