Technology Process of beta-Fluoromethylene-3-tyrosine
There total 8 articles about beta-Fluoromethylene-3-tyrosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 54 percent / KHF2 / various solvent(s) / 3 h / 100 °C
2: 80 percent / NaH / toluene / 0.5 h / < 15 deg C
3: Br2 / CCl4 / 3 h / -5 °C
4: piperidine / diethyl ether / 2.5 h / 5 °C
5: LDA / 0.5 h / -78 °C
6: NH3 / dimethylsulfoxide / 2.5 h / Ambient temperature
7: 1.) aq. HBr; 2.) propylene oxide / 1.) reflux, 4 h; 2.) MeOH, RT, 3 h
With
piperidine; potassium hydrogen bifluoride; ammonia; hydrogen bromide; bromine; sodium hydride; methyloxirane; lithium diisopropyl amide;
In
tetrachloromethane; diethyl ether; dimethyl sulfoxide; toluene;
DOI:10.1021/ja00323a050
- Guidance literature:
-
Multi-step reaction with 4 steps
1: piperidine / diethyl ether / 2.5 h / 5 °C
2: LDA / 0.5 h / -78 °C
3: NH3 / dimethylsulfoxide / 2.5 h / Ambient temperature
4: 1.) aq. HBr; 2.) propylene oxide / 1.) reflux, 4 h; 2.) MeOH, RT, 3 h
With
piperidine; ammonia; hydrogen bromide; methyloxirane; lithium diisopropyl amide;
In
diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ja00323a050
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LDA / 0.5 h / -78 °C
2: NH3 / dimethylsulfoxide / 2.5 h / Ambient temperature
3: 1.) aq. HBr; 2.) propylene oxide / 1.) reflux, 4 h; 2.) MeOH, RT, 3 h
With
ammonia; hydrogen bromide; methyloxirane; lithium diisopropyl amide;
In
dimethyl sulfoxide;
DOI:10.1021/ja00323a050
