(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate
CAS No.:1200498-30-1
Molecular Formula:C₁₆H₁₉BrF₂N₂O₂S
Molecular Weight:421.306
Hs Code.:

Synonyms:(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

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Chemical Property of (S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

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Technology Process of (S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

There total 6 articles about (S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1200498-28-7
C₁₁H₁₁BrF₂N₂S

: 1200498-30-1
(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 1200498-30-1
(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 0 °C

1.3: 0 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / -78 °C

2.2: 3 h / -78 - 0 °C

2.3: 0 °C

3.1: potassium hydroxide; water / ethanol / 4 h / Reflux

4.1: hydrogenchloride / acetic acid / 40 - 50 °C

5.1: trifluoroacetic acid; sulfuric acid / 7 h / 60 °C

6.1: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; sulfuric acid; water; diisopropylamine; trifluoroacetic acid; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; acetic acid;

Reference yield:

: 1200498-24-3
C₁₀H₉BrF₂O

: 1200498-30-1
(S)-tert-butyl 4-(5-bromo-2,4-difluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetic acid / 40 - 50 °C

2: trifluoroacetic acid; sulfuric acid / 7 h / 60 °C

3: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sulfuric acid; trifluoroacetic acid; In tetrahydrofuran; acetic acid;