[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

Base Information

Chemical Name:[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine
CAS No.:1428766-60-2
Molecular Formula:C₁₈H₁₉BrN₂O₂S
Molecular Weight:407.331
Hs Code.:

Synonyms:[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

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Chemical Property of [2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

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Technology Process of [2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

There total 6 articles about [2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1428766-59-9
2-bromomethyl-1-tosylaziridine-2-carboxaldehyde

: 100-46-9
benzylamine

: 1428766-60-2
[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

Guidance literature:: With magnesium sulfate; In dichloromethane; for 2h; Reflux;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1092540-02-7
ethyl 2-{[(4-methylbenzene)sulfonamido]methyl}acrylate

: 1428766-60-2
[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / dichloromethane / 24 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 2 h / 60 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

4: magnesium sulfate / dichloromethane / 2 h / Reflux

With lithium aluminium tetrahydride; bromine; magnesium sulfate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065

Reference yield:

: 1092540-15-2
ethyl 2,3-dibromo-2-[(tosylamino)methyl]propanoate

: 1428766-60-2
[2-bromomethyl-1-(toluene-4-sulfonyl)-aziridin-2-ylmethylene]-benzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / 60 °C

2: lithium aluminium tetrahydride / diethyl ether / 1 h / -78 °C

3: magnesium sulfate / dichloromethane / 2 h / Reflux

With lithium aluminium tetrahydride; magnesium sulfate; potassium carbonate; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.02.065