Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

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Chemical Name:Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester
CAS No.:862973-22-6
Molecular Formula:C₁₇H₂₇F₃O₇S
Molecular Weight:432.458
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

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Technology Process of Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

There total 4 articles about Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 862973-15-7
1-[(1R,2R)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4,4-dimethoxy-1-methylcyclohexyl]ethan-1-one

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 862973-22-6
Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

Guidance literature:: 1-[(1R,2R)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4,4-dimethoxy-1-methylcyclohexyl]ethan-1-one; With potassium hexamethylsilazane; In tetrahydrofuran;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1055/s-2005-869843

Reference yield:

: 862973-12-4
(4R,5R)-4-acetyl-5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methyl-2-cyclohexen-1-one

: 862973-22-6
Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / H₂ / Pd/C / ethyl acetate / 10 h / 20 °C / 760 Torr

2: 75 percent / PPTS / 2.5 h / 0 °C

3: KN(SiMe₃)2 / toluene; tetrahydrofuran / 1 h / -78 °C

With hydrogen; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jo0610208

Reference yield:

: 82042-36-2
(E)-1,3,4-trideoxy-5,6-O-isopropylidene-3-C-methyl-D-glycero-hex-3-eno-2-ulose

: 862973-22-6
Trifluoro-methanesulfonic acid 1-[(1R,2R)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,4-dimethoxy-1-methyl-cyclohexyl]-vinyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 72 h / 150 °C

1.2: 66 percent / aq. HCl / tetrahydrofuran / 0.5 h / 20 °C

2.1: 89 percent / H₂ / Pd/C / ethyl acetate / 10 h / 20 °C / 760 Torr

3.1: 75 percent / PPTS / 2.5 h / 0 °C

4.1: KN(SiMe₃)2 / toluene; tetrahydrofuran / 1 h / -78 °C

With hydrogen; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene; 1.1: intermolecular Diels-Alder reaction;
DOI:10.1021/jo0610208