(E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

Base Information

Chemical Name:(E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate
CAS No.:944419-68-5
Molecular Formula:C₁₇H₂₂F₃NO₂
Molecular Weight:329.362
Hs Code.:

Synonyms:(E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

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Chemical Property of (E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

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Technology Process of (E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

There total 2 articles about (E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 71740-33-5
N,N-dimethyl-1-(4-(trifluoromethyl)phenyl)methanamine

: 944419-68-5
(E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

Guidance literature:: With copper diacetate; acetic acid; palladium dichloride; In 2,2,2-trifluoroethanol; at 85 ℃; for 48h;
DOI:10.1021/ja070588a

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 944419-68-5
(E)-butyl 3-(2-((dimethylamino)methyl)-5-(trifluromethyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NEt₃; Ti(i-PrO)4 / ethanol / 12 h / 25 °C

1.2: NaBH₄ / ethanol / 10 h / 25 °C

2.1: 123 mg / Cu(OAc)2; AcOH / PdCl₂ / 2,2,2-trifluoro-ethanol / 48 h / 85 °C

With titanium(IV) isopropylate; copper diacetate; acetic acid; triethylamine; palladium dichloride; In ethanol; 2,2,2-trifluoroethanol;
DOI:10.1021/ja070588a