2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

Base Information

Chemical Name:2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide
CAS No.:179625-68-4
Molecular Formula:C₂₀H₂₀ClN₃O₂
Molecular Weight:369.851
Hs Code.:

Synonyms:2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

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Chemical Property of 2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

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Technology Process of 2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

There total 7 articles about 2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179625-67-3
8-[2-Chloro-5-[N-methyl-N-(phthalimidoacetyl)amino]-benzyloxy]-2-methylquinoline

: 179625-68-4
2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Heating;
DOI:10.1021/jm980330i

Reference yield:

: 826-81-3
2-methyl-8-quinolinol

: 179625-68-4
2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

2: 54.8 percent / Fe, AcOH / ethanol / 3 h / Heating

3: 4-(dimethylamino)pyridine, pyridine / various solvent(s) / 2 h / 50 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

5: H₂NNH₂*H₂O / ethanol / 1 h / Heating

With pyridine; dmap; iron; sodium hydride; hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1021/jm980330i

Reference yield:

: 80866-80-4
2-chloro-5-nitrobenzyl alcohol

: 179625-68-4
2-Amino-N-[4-chloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 0.5 h

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: 54.8 percent / Fe, AcOH / ethanol / 3 h / Heating

4: 4-(dimethylamino)pyridine, pyridine / various solvent(s) / 2 h / 50 °C

5: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

6: H₂NNH₂*H₂O / ethanol / 1 h / Heating

With pyridine; dmap; iron; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/jm980330i