2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Base Information

• Chemical Name: 2-ethylbutyl (S)-2-aminopropanoate hydrochloride
• CAS No.: 946511-97-3
• Molecular Formula: C₉H₁₉NO₂*ClH
• Molecular Weight: 209.716
• Mol file: 946511-97-3.mol

Synonyms:2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Chemical Property of 2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Chemical Property:

• Melting Point: 77 - 79°C

Purity/Quality:

99%min, ^*data from raw suppliers

L-Alanine2-ethylbutylesterHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.

Technology Process of 2-ethylbutyl (S)-2-aminopropanoate hydrochloride

There total 4 articles about 2-ethylbutyl (S)-2-aminopropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

L-N-Boc-Ala (15761-38-3) + 2-ethyl-1-butanol (97-95-0) → 2-ethylbutyl (S)-2-aminopropanoate hydrochloride (946511-97-3)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 18h;

Reference yield: 80.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + 2-ethyl-1-butanol (97-95-0) → 2-ethylbutyl (S)-2-aminopropanoate hydrochloride (946511-97-3)

Guidance literature:

L-alanin; 2-ethyl-1-butanol; at 0 ℃; for 0.0833333h;

With thionyl chloride; at 60 ℃; for 10h;

Reference yield: 78.0%

→ 2-ethylbutyl (S)-2-aminopropanoate hydrochloride (946511-97-3)

Guidance literature:

With chloro-trimethyl-silane; In dichloromethane;

upstream raw materials:

C₁₄H₂₇NO₄

L-alanin

2-ethyl-1-butanol

L-N-Boc-Ala

Downstream raw materials:

(2S)-2-ethylbutyl 2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate

(2S)-2-ethylbutyl 2-(((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

(2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester

(2S)-2-ethylbutyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate