C₂₇H₃₅N₆O₈P

Base Information

• Chemical Name: C₂₇H₃₅N₆O₈P
• CAS No.: 1911578-75-0
• Molecular Formula: C₂₇H₃₅N₆O₈P
• Molecular Weight: 602.584
• Mol file: 1911578-75-0.mol

Synonyms:

Chemical Property of C₂₇H₃₅N₆O₈P

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₅N₆O₈P

There total 136 articles about C₂₇H₃₅N₆O₈P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine (1770840-43-1) → (2S)-2-ethylbutyl 2-(((R)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1911578-75-0) + (2S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1809249-37-3,1911578-75-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: chloro-trimethyl-silane; phenylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 - 5 °C / Inert atmosphere

1.2: 0.17 h / -15 - -12 °C

1.3: 1 h / -20 °C

2.1: dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C

3.1: boron trichloride / dichloromethane / 1 h / -78 °C / Inert atmosphere

4.1: 1-methyl-1H-imidazole / tetrahydrofuran / 0 °C / Inert atmosphere

5.1: Lux Cellulose-2 chiral column / acetonitrile; methanol / Resolution of racemate

With 1-methyl-1H-imidazole; chloro-trimethyl-silane; phenylmagnesium chloride; boron trichloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

O-phenyl phosphorodichloridate (770-12-7) → (2S)-2-ethylbutyl 2-(((R)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1911578-75-0) + (2S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1809249-37-3,1911578-75-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 4 h / -78 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C

2.1: tert-butylmagnesium chloride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 20 °C

3.1: Lux Cellulose-2 chiral column / acetonitrile; methanol / Resolution of racemate

With tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile (1191237-69-0) → (2S)-2-ethylbutyl 2-(((R)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1911578-75-0) + (2S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (1809249-37-3,1911578-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-1H-imidazole / tetrahydrofuran / 0 °C / Inert atmosphere

2: Lux Cellulose-2 chiral column / acetonitrile; methanol / Resolution of racemate

With 1-methyl-1H-imidazole; In tetrahydrofuran; methanol; acetonitrile;

upstream raw materials:

(3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol

(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile

(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile

(2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoic acid 2-ethylbutyl ester

Downstream raw materials:

GS-704277