(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Base Information

Chemical Name:(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne
CAS No.:862259-74-3
Molecular Formula:C₄₈H₇₄O₂Si₂
Molecular Weight:739.285
Hs Code.:

Synonyms:(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Suppliers and Price of (20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

There total 7 articles about (20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 862259-66-3
(20R)-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-3-triisopropylsilyl-2-propyn-1-ol

: 74-88-4
methyl iodide

: 862259-74-3
(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Guidance literature:: (20R)-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-3-triisopropylsilyl-2-propyn-1-ol; With sodium hydride; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; hexane; at 20 ℃; for 5h;
DOI:10.1021/jm050271q

Reference yield:

: 862259-67-4
3α-(tert-butyldiphenylsilyloxy)-5α-pregnan-20-one

: 862259-74-3
(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / NaOBr / dioxane; H₂O / 24 h / 20 °C

2.1: 98 percent / EDCI; DMAP / CH₂Cl₂ / 2 h / 20 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -40 °C

3.2: 70 percent / tetrahydrofuran; hexane / 2 h / -10 °C

4.1: 93 percent / (S)-3,3-diPh-1-Me-4hydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole; borane methyl sulfide / tetrahydrofuran; toluene / -30 °C

5.1: NaH / hexane; tetrahydrofuran / 0.5 h / 20 °C

5.2: 70 percent / hexane; tetrahydrofuran / 5 h / 20 °C

With dmap; n-butyllithium; sodium hypobromide; dimethylsulfide borane complex; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; toluene;
DOI:10.1021/jm050271q

Reference yield:

: 862259-60-7
3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-carboxylic acid

: 862259-74-3
(20R)-3-triisopropylsilyl-1-methoxy-1-[3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-yl]-2-propyne

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / EDCI; DMAP / CH₂Cl₂ / 2 h / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -40 °C

2.2: 70 percent / tetrahydrofuran; hexane / 2 h / -10 °C

3.1: 93 percent / (S)-3,3-diPh-1-Me-4hydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole; borane methyl sulfide / tetrahydrofuran; toluene / -30 °C

4.1: NaH / hexane; tetrahydrofuran / 0.5 h / 20 °C

4.2: 70 percent / hexane; tetrahydrofuran / 5 h / 20 °C

With dmap; n-butyllithium; dimethylsulfide borane complex; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/jm050271q