N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine

Base Information

• Chemical Name: N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine
• CAS No.: 1041170-88-0
• Molecular Formula: C₃₀H₄₀N₂O₉S
• Molecular Weight: 604.722
• Mol file: 1041170-88-0.mol

Synonyms:N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine

Chemical Property of N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine

There total 2 articles about N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

S-(4-methoxybenzyl)-L-cysteine (2544-31-2) + N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester (790244-47-2) → N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine (1041170-88-0)

Guidance literature:

N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -12 ℃; for 0.5h;

S-(4-methoxybenzyl)-L-cysteine; With triethylamine; In tetrahydrofuran; water; at 0 - 20 ℃; for 1.83333h;

DOI:10.1021/ja8005397

Reference yield:

S-(4-methoxybenzyl)-L-cysteine (2544-31-2) + 2-tert-butoxycarbonylamino-6-isobutoxycarbonyloxy-6-oxo-hexanoic acid 4-methoxy-benzyl ester → N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine (1041170-88-0)

Guidance literature:

With water; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.1039/b910170e

Reference yield: 63.0%

C8H16O3S (1041170-89-1) + N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine (1041170-88-0) → C36H50N2O11S2

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Sonication;

DOI:10.1021/ja8005397

upstream raw materials:

S-(4-methoxybenzyl)-L-cysteine

N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester

Downstream raw materials:

C₃₈H₅₄N₂O₁₁S₂