N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester

Base Information

• Chemical Name: N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester
• CAS No.: 790244-47-2
• Molecular Formula: C₁₉H₂₇NO₇
• Molecular Weight: 381.426
• Mol file: 790244-47-2.mol

Synonyms:N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester

Chemical Property of N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester

There total 3 articles about N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Nα-(tert-butoxycarbonyl)-L-α-aminoadipic acid (77302-72-8) + p-methoxybenzyl chloride (824-94-2) → N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester (790244-47-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 38 ℃;

DOI:10.1002/cbic.201200728

Reference yield:

L-homoglutamic acid (1118-90-7) → N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester (790244-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 48 h / 20 °C

2: 53 percent / Et₃N / dimethylformamide / 24 h / 35 °C

With sodium hydroxide; triethylamine; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1039/b212270g

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-tert-butyloxycarbonyl-L-α-aminoadipic acid α-p-methoxybenzyl ester (790244-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 48 h / 20 °C

2: 53 percent / Et₃N / dimethylformamide / 24 h / 35 °C

With sodium hydroxide; triethylamine; In N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1039/b212270g

upstream raw materials:

N^α-(tert-butoxycarbonyl)-L-α-aminoadipic acid

p-methoxybenzyl chloride

L-homoglutamic acid

di-tert-butyl dicarbonate

Downstream raw materials:

N-tert-butyloxycarbonyl-α-p-methoxybenzyl-δ-(L-α-aminoadipoyl)-S-p-methoxybenzyl-L-cysteine

(S)-5-((R)-2-Benzhydrylsulfanyl-1-carboxy-ethylcarbamoyl)-2-tert-butoxycarbonylamino-pentanoic acid 4-methoxy-benzyl ester