5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Base Information

Chemical Name:5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone
CAS No.:146395-79-1
Molecular Formula:C₂₅H₂₉Cl₂NO₃
Molecular Weight:462.416
Hs Code.:

Synonyms:5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Suppliers and Price of 5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

There total 6 articles about 5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 146395-78-0
5-(3,4-dichlorophenyl)-5-[2-(tetrahydropyran-2-yloxy) ethyl]piperidine-2-one

: 146395-79-1
5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Guidance literature:: 5-(3,4-dichlorophenyl)-5-[2-(tetrahydropyran-2-yloxy) ethyl]piperidine-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

benzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Further stages.;
DOI:10.1021/jm0209331

Reference yield:

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 146395-79-1
5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.5 h

1.2: 34 percent / tetrahydrofuran / 20 °C

2.1: LDA / tetrahydrofuran / -78 - 20 °C

2.2: 61 percent / tertbutylammonium iodide / tetrahydrofuran / 20 °C

3.1: 75 percent / H₂; NH₃ / Raney nickel / ethanol / 14 h / 20 °C

4.1: NaH / dimethylformamide / 0.67 h / 20 °C

4.2: 91 percent / dimethylformamide / 0.5 h / 0 °C

With ammonia; hydrogen; sodium hydride; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0209331

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 146395-79-1
5-Tetrahydropyranyloxyethyl-5-(3,4-dichlorophenyl)-1-benzylpiperidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.5 h

1.2: 34 percent / tetrahydrofuran / 20 °C

2.1: LDA / tetrahydrofuran / -78 - 20 °C

2.2: 61 percent / tertbutylammonium iodide / tetrahydrofuran / 20 °C

3.1: 75 percent / H₂; NH₃ / Raney nickel / ethanol / 14 h / 20 °C

4.1: NaH / dimethylformamide / 0.67 h / 20 °C

4.2: 91 percent / dimethylformamide / 0.5 h / 0 °C

With ammonia; hydrogen; sodium hydride; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0209331