2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

Base Information

Chemical Name:2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine
CAS No.:70059-65-3
Molecular Formula:C₁₆H₁₄FN₃S
Molecular Weight:299.372
Hs Code.:

Synonyms:2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

Suppliers and Price of 2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

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Technology Process of 2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

There total 6 articles about 2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40493-18-3
4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

: 371-40-4
4-fluoroaniline

: 70059-65-3
2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

Guidance literature:: In isopropyl alcohol; for 0.333333h; microwave irradiation;
DOI:10.1016/j.tetlet.2007.11.135

Reference yield: 79.0%

: N'-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N,N-dimethylformimidamide

: 371-40-4
4-fluoroaniline

: 70059-65-3
2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

Guidance literature:: With acetic acid; at 90 ℃; for 0.166667h; under 10343.2 Torr; Microwave irradiation;
DOI:10.21577/0103-5053.20190044

Reference yield:

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 70059-65-3
2H-4-fluorophenyl-(5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4-yl)amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / Cooling with ice; Microwave irradiation

2: isopropyl alcohol / 0.83 h / Microwave irradiation

With trichlorophosphate; In isopropyl alcohol; 1: |Vilsmeier-Haack Formylation;
DOI:10.1080/00397911.2011.607934