(4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one

Base Information

• Chemical Name: (4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one
• CAS No.: 128576-81-8
• Molecular Formula: C₃₀H₂₄N₂O₃
• Molecular Weight: 460.532
• Mol file: 128576-81-8.mol

Synonyms:(4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one

Chemical Property of (4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one

There total 1 articles about (4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4R,5S)-4-benzyl-5-(methoxycarbonyl)-1-(9-phenylfluoren-9-yl)imidazolidin-2-one (128576-80-7) → (4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one (128576-81-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 72h;

DOI:10.1021/jo00304a011

Reference yield: 96.0%

(4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one (128576-81-8) → (4S,5R)-4-carboxy-5-benzylimidazolidin-2-one (128657-46-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃;

DOI:10.1021/jo00304a011

Reference yield:

(4R,5S)-4-benzyl-5-carboxy-1-(9-phenylfluoren-9-yl)-imidazolidin-2-one (128576-81-8) → (4S,5R)-5-benzyl-4-(methoxycarbonyl)imidazolidin-2-one (128576-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / trifluoroacetic acid / CH₂Cl₂ / 25 °C

2: thionyl chloride / 12 h / Ambient temperature

With thionyl chloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00304a011

upstream raw materials:

(4R,5S)-4-benzyl-5-(methoxycarbonyl)-1-(9-phenylfluoren-9-yl)imidazolidin-2-one

Downstream raw materials:

(4S,5R)-4-carboxy-5-benzylimidazolidin-2-one

(4S,5R)-5-benzyl-4-(methoxycarbonyl)imidazolidin-2-one

(2S,3R)-2,3-diamino-4-phenylbutanoic acid dihydrochloride