Technology Process of tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
There total 13 articles about tert-butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran;
at 70 ℃;
for 2h;
Inert atmosphere;
Sealed vessel;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / toluene; mineral oil / 110 °C
1.2: 48 h / 110 °C
1.3: 16 h / Reflux
2.1: tetrahydrofuran / 16 h / 65 °C
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere
4.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr
6.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
7.1: N-iodo-succinimide / dichloromethane / 0.83 h / 0 °C
8.1: bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere; Sealed vessel
With
N-iodo-succinimide; hydrogen; dihydrogen peroxide; potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydride / toluene; mineral oil / 0.83 h
1.2: 20 - 70 °C
1.3: 24 h / Reflux
2.1: tetrahydrofuran / 24 h / Reflux
3.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 11636.1 Torr
4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / ethanol; tetrahydrofuran / 50 °C / 10343.2 - 25858.1 Torr
5.1: palladium on carbon / toluene / 48 h / 80 °C
6.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
7.1: N-iodo-succinimide / dichloromethane / 0.83 h / 0 °C
8.1: bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere; Sealed vessel
With
N-iodo-succinimide; hydrogen; sodium hydride; caesium carbonate; acetic acid;
bis(tri-t-butylphosphine)palladium(0); 20 % Pd(OH)2/C; palladium on carbon; palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
![tert-Butyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-9-iodo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate](/Databaselist/images/loading.webp)
