5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride

Base Information

• Chemical Name: 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride
• CAS No.: 957204-07-8
• Molecular Formula: C₁₇H₁₃F₆NO*ClH
• Molecular Weight: 397.748
• Mol file: 957204-07-8.mol

Synonyms:5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride

Chemical Property of 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride

There total 1 articles about 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline (957204-06-7) → 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride (957204-07-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

Reference yield:

(R)-4-(tert-butoxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid (155542-33-9) + 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride (957204-07-8) → (R)-3-tert-Butoxycarbonylamino-4-oxo-4-[5-[3,5-bis-(trifluoromethyl)benzyloxy]indolin-1-yl]butyric acid tert-butyl ester (957204-08-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

upstream raw materials:

5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline

Downstream raw materials:

(R)-3-tert-Butoxycarbonylamino-4-oxo-4-[5-[3,5-bis-(trifluoromethyl)benzyloxy]indolin-1-yl]butyric acid tert-butyl ester