5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline

Base Information

• Chemical Name: 5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline
• CAS No.: 957204-06-7
• Molecular Formula: C₂₂H₂₁F₆NO₃
• Molecular Weight: 461.404
• Mol file: 957204-06-7.mol

Synonyms:5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline

Chemical Property of 5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline

There total 1 articles about 5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-bis(trifluoromethyl)benzyl chloride (75462-59-8) + tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate (170147-76-9) → 5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline (957204-06-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 14h;

Reference yield:

5-[3,5-Bis-(trifluoromethyl)benzyloxy]-1-tert-butoxycarbonylindoline (957204-06-7) → 5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride (957204-07-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

upstream raw materials:

3,5-bis(trifluoromethyl)benzyl chloride

tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate

Downstream raw materials:

5-[3,5-bis-(trifluoromethyl)benzyloxy]indoline hydrochloride