N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

Base Information

Chemical Name:N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide
CAS No.:1277186-25-0
Molecular Formula:C₃₂H₃₄N₂O₃S
Molecular Weight:526.7
Hs Code.:

Synonyms:N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

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Chemical Property of N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

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Technology Process of N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

There total 6 articles about N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 6976-91-6
N,N-dimethylmethacrylamide

: N-benzyl-N-(1-phenylvinyl)acetamide enamide

: 170751-34-5
N,N-bis(2-butynyl)-(4-methylphenyl)sulfonamide

: (+)-4,5,7-trimethyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindole-5-carboxylic acid dimethylamide

: 1277186-25-0
N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-segphos; In dichloromethane; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201004150

Reference yield:

: 6976-91-6
N,N-dimethylmethacrylamide

: N-benzyl-N-(1-phenylvinyl)acetamide enamide

: 170751-34-5
N,N-bis(2-butynyl)-(4-methylphenyl)sulfonamide

: 1042139-33-2
C₂₁H₂₈N₂O₃S

: 1277186-25-0
N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201004150

Reference yield:

: 100-46-9
benzylamine

: (+)-4,5,7-trimethyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindole-5-carboxylic acid dimethylamide

: 1277186-25-0
N-benzyl-N-[4,7-dimethyl-5-phenyl-2-(toluene-4-sulfonyl)-2,3,5,6-tetrahydro-1H-isoindol-5-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 2 h / 120 °C / Molecular sieve; Inert atmosphere

2: triethylamine / toluene / 0.5 h / 0 °C / Inert atmosphere

3: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-segphos / dichloromethane / 1 h / 20 °C / Inert atmosphere

With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; triethylamine; (R)-segphos; In dichloromethane; toluene;
DOI:10.1002/anie.201004150