N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

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Chemical Name:N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide
CAS No.:1355027-74-5
Molecular Formula:C₄₉H₇₇N₇O₉
Molecular Weight:908.192
Hs Code.:

Synonyms:N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

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Chemical Property of N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

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Technology Process of N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

There total 14 articles about N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1355027-73-4
methyl (20S,23S)-23-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl) acetyl]amino}-4-methylpentanoyl]amino}-2,2-dimethyl-4,19,22-trioxo-20-(propan-2-yl)-3-oxa-5,18,21-triazapentacosan-25-oate

: 1355027-74-5
N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

Guidance literature:: methyl (20S,23S)-23-{[(2S)-2-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl) acetyl]amino}-4-methylpentanoyl]amino}-2,2-dimethyl-4,19,22-trioxo-20-(propan-2-yl)-3-oxa-5,18,21-triazapentacosan-25-oate; With lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;

With hydrogenchloride; In water;
DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

: 1292797-89-7
C₂₈H₄₃N₃O₈

: 1355027-74-5
N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 2 h

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

3.1: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

4.2: Inert atmosphere

5.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.078

Reference yield:

: 1292797-85-3
C₂HF₃O₂*C₁₇H₂₄N₂O₅

: 1355027-74-5
N-[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-N-{12-[(tert-butoxycarbonyl)amino]dodecyl}-L-valinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane

2.1: dichloromethane / 2 h

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

4.1: palladium 10% on activated carbon; hydrogen / ethanol; N,N-dimethyl-formamide

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

5.2: Inert atmosphere

6.1: lithium hydroxide / methanol; water; N,N-dimethyl-formamide

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.078