Technology Process of N6-benzoyl-5'-deoxy-2',3'-O-isopropylidiene-5',5'-(N,N'-diphenylethylenediamino)adenosine
There total 8 articles about N6-benzoyl-5'-deoxy-2',3'-O-isopropylidiene-5',5'-(N,N'-diphenylethylenediamino)adenosine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-6-benzoyl-2',3'-O-isopropylideneadenosine;
With
dichloro-acetic acid; dicyclohexyl-carbodiimide;
In
dimethyl sulfoxide;
at 0 - 20 ℃;
for 2.5h;
With
oxalic acid;
In
methanol; dimethyl sulfoxide;
at 20 ℃;
for 0.5h;
N,N'-diphenylethylenediamine;
In
methanol; dimethyl sulfoxide;
at 20 ℃;
DOI:10.1039/c4ob02560a
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine
2: NaOH / pyridine
3: DMSO; dicyclohexylcarbodiimide; H+
With
pyridine; sodium hydroxide; hydrogen cation; dimethyl sulfoxide; dicyclohexyl-carbodiimide;
In
pyridine;
DOI:10.1016/j.tetasy.2003.11.007
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / 2 h / 0 - 20 °C
2.1: ammonium hydroxide / water / 0.5 h / 0 - 20 °C
3.1: dicyclohexyl-carbodiimide; dichloro-acetic acid / dimethyl sulfoxide / 2.5 h / 0 - 20 °C
3.2: 0.5 h / 20 °C
3.3: 20 °C
With
pyridine; dichloro-acetic acid; ammonium hydroxide; dicyclohexyl-carbodiimide;
In
water; dimethyl sulfoxide;
DOI:10.1039/c4ob02560a
