methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

Base Information

Chemical Name:methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate
CAS No.:1223446-46-5
Molecular Formula:C₁₆H₂₀ClFN₂O₄
Molecular Weight:358.797
Hs Code.:

Synonyms:methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

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Chemical Property of methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

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Technology Process of methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

There total 5 articles about methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1223445-62-2
methyl 5-acetyl-3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate

: 1223446-46-5
methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In methanol; at 18 - 25 ℃; for 12h;

Reference yield:

: 1223444-78-7
3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoic acid

: 1223446-46-5
methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 12 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -50 °C

2.2: 1 h / -50 °C

3.1: hydroxylamine hydrochloride; pyridine / methanol / 12 h / 20 °C

With pyridine; sulfuric acid; hydroxylamine hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/jm501174m

Reference yield:

: 1223444-87-8
methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluorobenzoate

: 1223446-46-5
methyl 3-chloro-2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-fluoro-5-[N-hydroxyethanimidoyl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -50 °C

1.2: 1 h / -50 °C

2.1: hydroxylamine hydrochloride; pyridine / methanol / 12 h / 20 °C

With pyridine; hydroxylamine hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1021/jm501174m