1223444-78-7Relevant articles and documents
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: Sar and in vivo characterization
Basarab, Gregory S.,Brassil, Patrick,Doig, Peter,Galullo, Vincent,Haimes, Howard B.,Kern, Gunther,Kutschke, Amy,McNulty, John,Schuck, Virna J. A.,Stone, Gregory,Gowravaram, Madhusudhan
, p. 9078 - 9095 (2014)
The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymi