25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene

Base Information

• Chemical Name: 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene
• CAS No.: 197796-03-5
• Molecular Formula: C₇₄H₈₄O₆
• Molecular Weight: 1069.48
• Mol file: 197796-03-5.mol

Synonyms:25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene

Chemical Property of 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene

There total 2 articles about 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene (197796-03-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / K₂CO₃ / acetone / 17 h / Heating

2: 93 percent / LiAlH₄ / diethyl ether / 4 h / Heating

3: 90 percent / pyridine / CHCl₃ / 0 °C

4: 65 percent / K₂CO₃ / acetonitrile / 40 h / Heating

With pyridine; lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; acetone; acetonitrile;

DOI:10.1007/BF00807096

Reference yield:

(4-benzyloxy-phenyl)-acetic acid methyl ester (68641-16-7) → 25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene (197796-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / LiAlH₄ / diethyl ether / 4 h / Heating

2: 90 percent / pyridine / CHCl₃ / 0 °C

3: 65 percent / K₂CO₃ / acetonitrile / 40 h / Heating

With pyridine; lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; acetonitrile;

DOI:10.1007/BF00807096

Reference yield: 94.0%

25,27-bis(2-(4-benzyloxyphenyl)ethoxy)-26,28-dihydroxy-p-tert-butylcalix[4]arene (197796-03-5) → 25,27-bis[2-(4-hydroxyphenyl)ethoxy]-26,28-dihydroxy-p-tert-butylcalix[4]arene (197796-05-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 7h;

DOI:10.1007/BF00807096

upstream raw materials:

Methyl 4-hydroxyphenylacetate

(4-benzyloxy-phenyl)-acetic acid methyl ester

Downstream raw materials:

25,27-bis[2-(4-hydroxyphenyl)ethoxy]-26,28-dihydroxy-p-tert-butylcalix[4]arene