68641-16-7

Basic information

• Product Name: 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER
• Synonyms: 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER;METHYL 4-BENZYLOXYPHENYLACETATE;methyl 2-(4-(benzyloxy)phenyl)acetate;Benzeneacetic acid, 4-(phenylmethoxy)-, methyl ester;methyl 2-(4-phenylmethoxyphenyl)acetate
• CAS NO: 68641-16-7
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.3
• Product Categories: Aromatic Esters
• Mol File: 68641-16-7.mol
• Article Data: 36

Chemical Properties

• Melting Point: 53 °C
• Boiling Point: 375 °C at 760 mmHg
• Flash Point: 157.3 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 8.02E-06mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER(68641-16-7)
• EPA Substance Registry System: 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER(68641-16-7)

Safety Data

• Hazardous Substances Data: 68641-16-7(Hazardous Substances Data)

Usage

General Description

4-Benzyloxyphenylacetic acid methyl ester is a chemical compound with the molecular formula C17H16O3. It is a methyl ester derivative of 4-benzyloxyphenylacetic acid, which is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical compounds. The compound has potential therapeutic effects and has been studied for its anti-inflammatory and analgesic properties. It is also used in the production of perfumes and flavoring agents due to its aromatic properties. Additionally, 4-benzyloxyphenylacetic acid methyl ester has been investigated for its potential role in drug delivery systems and as a precursor in organic synthesis. Overall, this compound has a wide range of potential applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C16H16O3/c1-18-16(17)11-13-7-9-15(10-8-13)19-12-14-5-3-2-4-6-14/h2-10H,11-12H2,1H3

Upstream product

• 67-56-1 methanol 
• 39188-62-0 2-(4-(benzyloxy)phenyl)acetyl chloride 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 100-39-0 benzyl bromide 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 100-44-7 benzyl chloride 
• 6547-53-1 2-[4-(benzyloxy)benzyl]acetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 186581-53-3 diazomethane 
• 838-96-0 2-[4-(benzyloxy)phenyl]acetonitrile 
• 584-08-7 potassium carbonate 
• 836-42-0 4-benzyloxybenzyl chloride 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 111751-72-5 methyl 2-(4'-benzyloxyphenyl)propenoate 
• 887259-38-3 methyl 2-[4-(benzyloxy)phenyl]-4-methoxy-3-oxobutanoate 
• 881672-56-6 2,2-dimethyl-propionic acid 3-hydroxy-2-(4-hydroxy-phenyl)-propyl ester 
• 155062-29-6 2-[4-(benzyloxy)phenyl]-1,3-propanediol 
• 881672-62-4 2-[4-(benzyloxy)phenyl]-3-hydroxypropyl pivalate 
• 223406-00-6 methyl 2-[4-(benzyloxy)phenyl]-2-methyl-4-oxobutanoate 
• 223405-99-0 2-(4-benzyloxy-phenyl)-2-methyl-pent-4-enoic acid methyl ester 
• 478911-32-9 methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate 
• 223406-02-8 methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate 
• 478911-64-7 (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester 
• 71851-34-8 5-(3',4'-dimethoxyphenyl)methylene-4-methoxy-3-(4''-methoxyphenyl)furan-2(5H)-one 
• 51282-12-3 3',4',4-trihydroxypulvinone 
• 93831-23-3 (Z)-5-benzylidene-4-hydroxy-3-(4-hydroxyphenyl)furan-2(5H)-one 
• 131146-40-2 3,4,4'-trihydroxypulvinone 

Relevant articles and documents

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

Palladium-catalyzed intermolecular C-H silylation initiated by aminopalladation

A Pd(ii)-catalyzed intermolecular C-H silylation reaction initiated by aminopalladation has been developed. The C-H bonds were activated by an alkyl Pd(ii) species generated through aminopalladation and then disilylated with hexamethyldisilane to form disilylated indolines as the final products. The reaction provides a new method for the introduction of silyl groups into complex organic molecules.

PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF

PROBLEM TO BE SOLVED: To provide compounds with excellent antimycotic activity against Trichophyton. SOLUTION: The invention provides pharmaceuticals comprising biaryl derivatives represented by general formula (I) or salts thereof, where ring A is optionally substituted phenyl or the like; Q is CH2 or the like; X1, X2 and X3 are CR1 or the like; and Y is CH or N. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT