(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Base Information

Chemical Name:(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride
CAS No.:1365889-59-3
Molecular Formula:C₂₈H₂₄ClFN₂O₂*ClH
Molecular Weight:511.423
Hs Code.:

Synonyms:(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Suppliers and Price of (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

There total 7 articles about (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365889-10-6
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

: 1365889-59-3
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 - 80 ℃; for 4.5h;

Reference yield:

: 478828-53-4
5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1365889-59-3
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

2.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

2.2: 4 - 20 °C / Inert atmosphere

2.3: 7 h / 75 °C / Inert atmosphere

3.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / ethanol / 4.5 h / 20 - 80 °C

With hydrogenchloride; copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(pinacol)diborane; lithium chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; ethanol; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1365889-59-3
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

3.2: 4 - 20 °C / Inert atmosphere

3.3: 7 h / 75 °C / Inert atmosphere

4.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride / ethanol / 4.5 h / 20 - 80 °C

With hydrogenchloride; copper(l) iodide; pyridinium p-toluenesulfonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(pinacol)diborane; lithium chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; acetonitrile;