(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Chemical Name:(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate
CAS No.:1365889-10-6
Molecular Formula:C₃₃H₃₂ClFN₂O₃
Molecular Weight:559.08
Hs Code.:

Synonyms:(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Chemical Property of (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

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Technology Process of (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

There total 12 articles about (E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1365889-09-3
(E)-4-(2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)benzaldehyde

: 1365889-10-6
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1365889-10-6
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

3.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

3.2: 4 - 20 °C / Inert atmosphere

3.3: 7 h / 75 °C / Inert atmosphere

4.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; pyridinium p-toluenesulfonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(pinacol)diborane; lithium chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: 478828-53-4
5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1365889-10-6
(E)-ethyl 3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; copper(l) iodide / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / ISOPROPYLAMIDE / 5 h / 80 °C / Inert atmosphere

2.1: bis(pinacol)diborane / tetrakis(triphenylphosphine)platinum / 2-methyltetrahydrofuran / 5 h / 83 °C / Inert atmosphere

2.2: 4 - 20 °C / Inert atmosphere

2.3: 7 h / 75 °C / Inert atmosphere

3.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

With copper(l) iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; bis(pinacol)diborane; lithium chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine)platinum; palladium diacetate; In 2-methyltetrahydrofuran; ISOPROPYLAMIDE; acetonitrile;